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    高師機構典藏 NKNUIR > 理學院 > 化學系 > 期刊論文 >  Item 987654321/23657
    Please use this identifier to cite or link to this item: http://ir.nknu.edu.tw/ir/handle/987654321/23657


    題名: Silver-Coated Gold Nanoparticles as Concentrating Probes and Matrices for Surface-Assisted Laser Desorption/Ionization Mass Spectrometric Analysis of Aminoglycosides
    Authors: 張玉珍
    Ming-Ta Wang;Ming-Han Liu;C. R. Chris Wang;Sarah Y. Chang
    Date: 2009-10
    Issue Date: 2015-04-27 11:34:46 (UTC+8)
    Abstract: A novel method for the determination of aminoglycosides by surface-assisted laser desorption/ionization mass spectrometry (SALDI MS) with the aid of silver-coated gold nanoparticles (Au@AgNPs) has been developed. The Au@AgNPs with surface capped by anionic citrate were used as concentrating probes as well as matrices in SALDI MS. Adsorption of aminoglycosides onto the nanoparticles was mainly through electrostatic attraction. The aminoglycoside-adsorbed nanoparticles were directly characterized by SALDI MS after a simple washing. Using Au@AgNPs to preconcentrate the aminoglycosides from 500 μL buffer solution, the limits of detection (LODs) at signal-to-noise ratio of 3 were 3, 25, 15, 30, and 38 nM for paromomycin, kanamycin A, neomycin, gentamicin, and apramycin, respectively. This method was successfully applied to the determination of aminoglycosides in human plasma samples. The LODs of aminoglycosides in plasma samples were 9, 130, 81, and 180 nM for paromomycin, kanamycin A, neomycin, and gentamicin, respectively. Recoveries of aminoglycosides in plasma samples were about 80%.
    關聯: Journal of the American Society for Mass Spectrometry / Volume 20, Issue 10, Pages 1925–1932
    2009 The 24th MicroScale Bioseparations, Dalian, China
    Appears in Collections:[化學系] 期刊論文
    [化學系] 張玉珍
    [化學系] 會議論文

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